CTLA-4 blockade decreases TGF-β, IDO, and viral RNA expression in tissues of SIVmac251-infected macaques

Regulatory T (T(reg)) cells are a subset of CD25(+)CD4(+) T cells that constitutively express high levels of cytotoxic T lymphocyte antigen-4 (CTLA-4) and suppress T-cell activation and effector functions. T(reg) cells are increased in tissues of individuals infected with HIV-1 and macaques infected...

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Detalhes bibliográficos
Principais autores: Hryniewicz, Anna, Boasso, Adriano, Edghill-Smith, Yvette, Vaccari, Monica, Fuchs, Dietmar, Venzon, David, Nacsa, Janos, Betts, Michael R., Tsai, Wen-Po, Heraud, Jean-Michel, Beer, Brigitte, Blanset, Diann, Chougnet, Claire, Lowy, Israel, Shearer, Gene M., Franchini, Genoveffa
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society of Hematology 2006
Assuntos:
Immunobiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895471/
https://ncbi.nlm.nih.gov/pubmed/16896154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2006-04-010637
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