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Establishment of a simple and efficient platform for car-t cell generation and expansion: from lentiviral production to in vivo studies
INTRODUCTION: Adoptive transfer of T cells expressing a CD19-specific chimeric antigen receptor (CAR) has shown impressive response rates for the treatment of CD19 + B-cell malignancies in numerous clinical trials. The CAR molecule, which recognizes cell-surface tumor-associated antigen independentl...
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| Publicado no: | Hematol Transfus Cell Ther |
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| Main Authors: | , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Sociedade Brasileira de Hematologia e Hemoterapia
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7248496/ https://ncbi.nlm.nih.gov/pubmed/31676276 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.htct.2019.06.007 |
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