Establishment of a simple and efficient platform for car-t cell generation and expansion: from lentiviral production to in vivo studies

INTRODUCTION: Adoptive transfer of T cells expressing a CD19-specific chimeric antigen receptor (CAR) has shown impressive response rates for the treatment of CD19 + B-cell malignancies in numerous clinical trials. The CAR molecule, which recognizes cell-surface tumor-associated antigen independentl...

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Bibliografische gegevens
Gepubliceerd in:Hematol Transfus Cell Ther
Hoofdauteurs: Picanço-Castro, Virgínia, Moço, Pablo Diego, Mizukami, Amanda, Vaz, Leticia Delfini, de Souza Fernandes Pereira, Marcelo, Silvestre, Renata Nacasaki, de Azevedo, Júlia Teixeira Cottas, de Sousa Bomfim, Aline, de Abreu Neto, Mario Soares, Malmegrim, Kelen Cristina Ribeiro, Swiech, Kamilla, Covas, Dimas Tadeu
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Sociedade Brasileira de Hematologia e Hemoterapia 2020
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Original Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7248496/
https://ncbi.nlm.nih.gov/pubmed/31676276
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.htct.2019.06.007
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