Mitochondrial Dysfunction and Calcium Dysregulation in Leigh Syndrome Induced Pluripotent Stem Cell Derived Neurons

Leigh syndrome (LS) is the most frequent infantile mitochondrial disorder (MD) and is characterized by neurodegeneration and astrogliosis in the basal ganglia or the brain stem. At present, there is no cure or treatment for this disease, partly due to scarcity of LS models. Current models generally...

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Bibliographic Details
Published in:Int J Mol Sci
Main Authors: Galera-Monge, Teresa, Zurita-Díaz, Francisco, Canals, Isaac, Grønning Hansen, Marita, Rufián-Vázquez, Laura, Ehinger, Johannes K., Elmér, Eskil, Martin, Miguel A., Garesse, Rafael, Ahlenius, Henrik, Gallardo, M. Esther
Format: Artigo
Language:Inglês
Published: MDPI 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7247580/
https://ncbi.nlm.nih.gov/pubmed/32366037
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21093191
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