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Repurposing Tyrosine Kinase Inhibitors to Overcome Multidrug Resistance in Cancer: A Focus on Transporters and Lysosomal Sequestration

Tyrosine kinase inhibitors (TKIs) are being increasingly used to treat various malignancies. Although they were designed to target aberrant tyrosine kinases, they are also intimately linked with the mechanisms of multidrug resistance (MDR) in cancer cells. MDR-related solute carrier (SLC) and ATB-bi...

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Foilsithe in:Int J Mol Sci
Main Authors: Krchniakova, Maria, Skoda, Jan, Neradil, Jakub, Chlapek, Petr, Veselska, Renata
Formáid: Artigo
Teanga:Inglês
Foilsithe: MDPI 2020
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7247577/
https://ncbi.nlm.nih.gov/pubmed/32365759
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21093157
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