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Novel Thiosemicarbazones Sensitize Pediatric Solid Tumor Cell-Types to Conventional Chemotherapeutics through Multiple Molecular Mechanisms

SIMPLE SUMMARY: Combination of chemotherapeutics for the treatment of childhood cancer can lead to the use of lower cytotoxic drug doses and better therapeutic tolerability (i.e., lower side effects) for patients. We discovered novel molecular targets of two lead thiosemicarbazone agents of the di-2...

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Detalhes bibliográficos
Publicado no:Cancers (Basel)
Main Authors: Paukovcekova, Silvia, Skoda, Jan, Neradil, Jakub, Mikulenkova, Erika, Chlapek, Petr, Sterba, Jaroslav, Richardson, Des R., Veselska, Renata
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7765366/
https://ncbi.nlm.nih.gov/pubmed/33334021
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers12123781
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