Symmetrically substituted dichlorophenes inhibit N-acyl-phosphatidylethanolamine phospholipase D

N-Acyl-phosphatidylethanolamine phospholipase D (NAPE-PLD) (EC 3.1.4.4) catalyzes the final step in the biosynthesis of N-acyl-ethanolamides. Reduced NAPE-PLD expression and activity may contribute to obesity and inflammation, but a lack of effective NAPE-PLD inhibitors has been a major obstacle to...

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Pubblicato in:J Biol Chem
Autori principali: Aggarwal, Geetika, Zarrow, Jonah E., Mashhadi, Zahra, Flynn, C. Robb, Vinson, Paige, Weaver, C. David, Davies, Sean S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2020
Soggetti:
Lipids
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7247316/
https://ncbi.nlm.nih.gov/pubmed/32284327
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.013362
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