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Inactivation of N-Acyl Phosphatidylethanolamine Phospholipase D Reveals Multiple Mechanisms for the Biosynthesis of Endocannabinoids

N-Acyl ethanolamines (NAEs) constitute a large and diverse class of signaling lipids that includes the endogenous cannabinoid anandamide. Like other lipid transmitters, NAEs are thought to be biosynthesized and degraded on-demand rather than being stored in vesicles prior to signaling. The identific...

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Autori principali: Leung, Donmienne, Saghatelian, Alan, Simon, Gabriel M., Cravatt, Benjamin F.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2006
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1538545/
https://ncbi.nlm.nih.gov/pubmed/16605240
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi060163l
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