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Characterization of mice lacking candidate N-acyl ethanolamine biosynthetic enzymes provides evidence for multiple pathways that contribute to endocannabinoid production in vivo

The biosynthesis of the endocannabinoid anandamide and related N-acyl ethanolamine (NAE) lipids is complex and appears to involve multiple pathways, including: 1) direct release of NAEs from N-acyl phosphatidyl ethanolamine (NAPE) precursors by the phosphodiesterase NAPE-PLD, and 2) double O-deacyla...

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Detalhes bibliográficos
Main Authors: Simon, Gabriel M., Cravatt, Benjamin F.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2946841/
https://ncbi.nlm.nih.gov/pubmed/20393650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c000237b
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