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O-GlcNAcylation of myosin phosphatase targeting subunit 1 (MYPT1) dictates timely disjunction of centrosomes

The role of O-linked N-acetylglucosamine (O-GlcNAc) modification in the cell cycle has been enigmatic. Previously, both O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA) disruptions have been shown to derail the mitotic centrosome numbers, suggesting that mitotic O-GlcNAc oscillation needs to be in c...

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Détails bibliographiques
Publié dans:J Biol Chem
Auteurs principaux: Liu, Caifei, Shi, Yingxin, Li, Jie, Liu, Xuewen, Xiahou, Zhikai, Tan, Zhongping, Chen, Xing, Li, Jing
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2020
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7247298/
https://ncbi.nlm.nih.gov/pubmed/32295844
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.012401
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