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De Novo Synthesis of the DEF-Ring Stereotriad Core of the Veratrum Alkaloids

The synthesis of the stereotriad core in the eastern portion of the Veratrum alkaloids jervine (1), cyclopamine (2), and veratramine (3) is reported. Starting from a known β-methyltyrosine derivative (8), the route utilizes a diastereoselective substrate-controlled 1,2-reduction to establish the ste...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Org Chem
Prif Awduron: Horwitz, Matthew A., Robins, Jacob G., Johnson, Jeffrey S.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2020
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7246867/
https://ncbi.nlm.nih.gov/pubmed/32352768
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.joc.0c00685
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