Orphan Nuclear Receptor RORα Regulates Enzymatic Metabolism of Cerebral 24S-Hydroxycholesterol through CYP39A1 Intronic Response Element Activation

Oxysterols, important regulators of cholesterol homeostasis in the brain, are affected by neurodegenerative diseases. Early-onset Alzheimer’s disease is associated with higher levels of circulating brain-derived 24S-hydroxycholesterol (24S-OHC). Conversion of cholesterol to 24S-OHC is mediated by ch...

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Publicat a:Int J Mol Sci
Autors principals: Matsuoka, Hiroshi, Katayama, Miyu, Ohishi, Ami, Miya, Kaoruko, Tokunaga, Riki, Kobayashi, Sou, Nishimoto, Yuya, Hirooka, Kazutake, Shima, Akiho, Michihara, Akihiro
Format: Artigo
Idioma:Inglês
Publicat: MDPI 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7246805/
https://ncbi.nlm.nih.gov/pubmed/32392803
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21093309
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