Retinoic acid receptor-related orphan receptor α reduces lipid droplets by upregulating neutral cholesterol ester hydrolase 1 in macrophages

BACKGROUND: Neutral cholesterol ester hydrolase 1 (NCEH1) catalyzes the hydrolysis of cholesterol ester (CE) in macrophages. Genetic ablation of NCEH1 promotes CE-laden macrophages and the development of atherosclerosis in mice. Dysregulation of NCEH1 levels is involved in the pathogenesis of multip...

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Detalhes bibliográficos
Publicado no:BMC Mol Cell Biol
Main Authors: Matsuoka, Hiroshi, Tokunaga, Riki, Katayama, Miyu, Hosoda, Yuichiro, Miya, Kaoruko, Sumi, Kento, Ohishi, Ami, Kamishikiryo, Jun, Shima, Akiho, Michihara, Akihiro
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7310410/
https://ncbi.nlm.nih.gov/pubmed/32321446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12860-020-00276-z
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