TFEB-NF-κB inflammatory signaling axis: a novel therapeutic pathway of Dihydrotanshinone I in doxorubicin-induced cardiotoxicity

BACKGROUND: Doxorubicin is effective in a variety of solid and hematological malignancies. Unfortunately, clinical application of doxorubicin is limited due to a cumulative dose-dependent cardiotoxicity. Dihydrotanshinone I (DHT) is a natural product from Salvia miltiorrhiza Bunge with multiple anti...

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Publicat a:J Exp Clin Cancer Res
Autors principals: Wang, Xiaoping, Wang, Qiyan, Li, Weili, Zhang, Qian, Jiang, Yanyan, Guo, Dongqing, Sun, Xiaoqian, Lu, Wenji, Li, Chun, Wang, Yong
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2020
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7245789/
https://ncbi.nlm.nih.gov/pubmed/32448281
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-020-01595-x
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