Positive epistasis between viral polymerase and the 3′ untranslated region of its genome reveals the epidemiologic fitness of dengue virus

Dengue virus (DENV) is a global health threat, causing repeated epidemics throughout the tropical world. While low herd immunity levels to any one of the four antigenic types of DENV predispose populations to outbreaks, viral genetic determinants that confer greater fitness for epidemic spread is an...

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Publicado en:Proc Natl Acad Sci U S A
Autores principales: Syenina, Ayesa, Vijaykrishna, Dhanasekaran, Gan, Esther Shuyi, Tan, Hwee Cheng, Choy, Milly M., Siriphanitchakorn, Tanamas, Cheng, Colin, Vasudevan, Subhash G., Ooi, Eng Eong
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2020
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7245076/
https://ncbi.nlm.nih.gov/pubmed/32366663
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1919287117
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