The biomarker HE4 (WFDC2) promotes a pro-angiogenic and immunosuppressive tumor microenvironment via regulation of STAT3 target genes

Epithelial ovarian cancer (EOC) is a highly lethal gynecologic malignancy arising from the fallopian tubes that has a high rate of chemoresistant recurrence and low five-year survival rate. The ovarian cancer biomarker HE4 is known to promote proliferation, metastasis, chemoresistance, and suppressi...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: James, Nicole E., Emerson, Jenna B., Borgstadt, Ashley D., Beffa, Lindsey, Oliver, Matthew T., Hovanesian, Virginia, Urh, Anze, Singh, Rakesh K., Rowswell-Turner, Rachael, DiSilvestro, Paul A., Ou, Joyce, Moore, Richard G., Ribeiro, Jennifer R.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7244765/
https://ncbi.nlm.nih.gov/pubmed/32444701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-65353-x
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