Methylation of a CGATA element inhibits binding and regulation by GATA-1

Alterations in DNA methylation occur during development, but the mechanisms by which they influence gene expression remain uncertain. There are few examples where modification of a single CpG dinucleotide directly affects transcription factor binding and regulation of a target gene in vivo. Here, we...

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Bibliografiska uppgifter
I publikationen:Nat Commun
Huvudupphovsmän: Yang, Lu, Chen, Zhiliang, Stout, Elizabeth S., Delerue, Fabien, Ittner, Lars M., Wilkins, Marc R., Quinlan, Kate G. R., Crossley, Merlin
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group UK 2020
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7244756/
https://ncbi.nlm.nih.gov/pubmed/32444652
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-16388-1
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