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Agonist-induced phosphorylation bar code and differential post-activation signaling of the delta opioid receptor revealed by phosphosite-specific antibodies

The δ-opioid receptor (DOP) is an attractive pharmacological target due to its potent analgesic, anxiolytic and anti-depressant activity in chronic pain models. However, some but not all selective DOP agonists also produce severe adverse effects such as seizures. Thus, the development of novel agoni...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Sci Rep
Prif Awduron: Mann, Anika, Liebetrau, Sophia, Klima, Marie, Dasgupta, Pooja, Massotte, Dominique, Schulz, Stefan
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group UK 2020
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7244497/
https://ncbi.nlm.nih.gov/pubmed/32444688
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-65589-7
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