Muscarinic M1 receptors modulate working memory performance and activity via KCNQ potassium channels in primate prefrontal cortex

Working memory relies on dorsolateral prefrontal cortex (dlPFC), where microcircuits of pyramidal neurons enable persistent firing in the absence of sensory input, maintaining information through recurrent excitation. This activity relies on acetylcholine, though the molecular mechanisms for this de...

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Détails bibliographiques
Publié dans:Neuron
Auteurs principaux: Galvin, Veronica C, Yang, Sheng Tao, Paspalas, Constantinos D, Yang, Yang, Jin, Lu E, Datta, D, Morozov, Yury M, Lightbourne, Taber C, Lowet, Adam S, Rakic, Pasko, Arnsten, Amy FT, Wang, Min
Format: Artigo
Langue:Inglês
Publié: 2020
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7244366/
https://ncbi.nlm.nih.gov/pubmed/32197063
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2020.02.030
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