Muscarinic M1 receptors modulate working memory performance and activity via KCNQ potassium channels in primate prefrontal cortex

Working memory relies on dorsolateral prefrontal cortex (dlPFC), where microcircuits of pyramidal neurons enable persistent firing in the absence of sensory input, maintaining information through recurrent excitation. This activity relies on acetylcholine, though the molecular mechanisms for this de...

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Detalhes bibliográficos
Publicado no:Neuron
Main Authors: Galvin, Veronica C, Yang, Sheng Tao, Paspalas, Constantinos D, Yang, Yang, Jin, Lu E, Datta, D, Morozov, Yury M, Lightbourne, Taber C, Lowet, Adam S, Rakic, Pasko, Arnsten, Amy FT, Wang, Min
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7244366/
https://ncbi.nlm.nih.gov/pubmed/32197063
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2020.02.030
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