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Parallel CRISPR-Cas9 screens clarify impacts of p53 on screen performance
CRISPR-Cas9 genome engineering has revolutionised high-throughput functional genomic screens. However, recent work has raised concerns regarding the performance of CRISPR-Cas9 screens using TP53 wild-type human cells due to a p53-mediated DNA damage response (DDR) limiting the efficiency of generati...
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| Publicado en: | eLife |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
eLife Sciences Publications, Ltd
2020
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7244323/ https://ncbi.nlm.nih.gov/pubmed/32441252 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.55325 |
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