Efficient blockade of locally reciprocated tumor-macrophage signaling using a TAM-avid nanotherapy

Interpreting how multicellular interactions in the tumor affect resistance pathways to BRAF and MEK1/2 MAPK inhibitors (MAPKi) remains a challenge. To investigate this, we profiled global ligand-receptor interactions among tumor and stromal/immune cells from biopsies of MAPK-driven disease. MAPKi in...

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Publicado en:Sci Adv
Main Authors: Wang, Stephanie J., Li, Ran, Ng, Thomas S. C., Luthria, Gaurav, Oudin, Madeleine J., Prytyskach, Mark, Kohler, Rainer H., Weissleder, Ralph, Lauffenburger, Douglas A., Miller, Miles A.
Formato: Artigo
Idioma:Inglês
Publicado: American Association for the Advancement of Science 2020
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Research Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7244320/
https://ncbi.nlm.nih.gov/pubmed/32494745
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aaz8521
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