Characterization of imine reductases in reductive amination for the exploration of structure-activity relationships

Imine reductases (IREDs) have shown great potential as catalysts for the asymmetric synthesis of industrially relevant chiral amines, but a limited understanding of sequence activity relationships makes rational engineering challenging. Here, we describe the characterization of 80 putative and 15 pr...

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Detalhes bibliográficos
Publicado no:Sci Adv
Main Authors: Montgomery, Sarah L., Pushpanath, Ahir, Heath, Rachel S., Marshall, James R., Klemstein, Ulrike, Galman, James L., Woodlock, David, Bisagni, Serena, Taylor, Christopher J., Mangas-Sanchez, J., Ramsden, J. I., Dominguez, Beatriz, Turner, Nicholas J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Association for the Advancement of Science 2020
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7244260/
https://ncbi.nlm.nih.gov/pubmed/32494734
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aay9320
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