LRRK2 Kinase Inhibition Rescues Deficits in Lysosome Function Due to Heterozygous GBA1 Expression in Human iPSC-Derived Neurons

A growing number of genes associated with Parkinson’s disease are implicated in the regulation of lysosome function, including LRRK2, whose missense mutations are perhaps the most common monogenic cause of this neurodegenerative disease. These mutations are collectively thought to introduce a pathol...

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Udgivet i:Front Neurosci
Main Authors: Sanyal, Anwesha, Novis, Hailey S., Gasser, Emile, Lin, Steven, LaVoie, Matthew J.
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2020
Fag:
Neuroscience
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7243441/
https://ncbi.nlm.nih.gov/pubmed/32499675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnins.2020.00442
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