Structural Basis for RNA Replication by the SARS-CoV-2 Polymerase

Nucleotide analog inhibitors, including broad-spectrum remdesivir and favipiravir, have shown promise in in vitro assays and some clinical studies for COVID-19 treatment, this despite an incomplete mechanistic understanding of the viral RNA-dependent RNA polymerase nsp12 drug interactions. Here, we...

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Publicado en:Cell
Autores principales: Wang, Quan, Wu, Jiqin, Wang, Haofeng, Gao, Yan, Liu, Qiaojie, Mu, An, Ji, Wenxin, Yan, Liming, Zhu, Yan, Zhu, Chen, Fang, Xiang, Yang, Xiaobao, Huang, Yucen, Gao, Hailong, Liu, Fengjiang, Ge, Ji, Sun, Qianqian, Yang, Xiuna, Xu, Wenqing, Liu, Zhijie, Yang, Haitao, Lou, Zhiyong, Jiang, Biao, Guddat, Luke W., Gong, Peng, Rao, Zihe
Formato: Artigo
Lenguaje:Inglês
Publicado: Elsevier Inc. 2020
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7242921/
https://ncbi.nlm.nih.gov/pubmed/32526208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2020.05.034
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