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High cell density increases glioblastoma cell viability under glucose deprivation via degradation of the cystine/glutamate transporter xCT (SLC7A11)

The cystine/glutamate transporter system x(c)(−) consists of the light-chain subunit xCT (SLC7A11) and the heavy-chain subunit CD98 (4F2hc or SLC3A2) and exchanges extracellular cystine for intracellular glutamate at the plasma membrane. The imported cystine is reduced to cysteine and used for synth...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Yamaguchi, Itsuki, Yoshimura, Shige H., Katoh, Hironori
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7242691/
https://ncbi.nlm.nih.gov/pubmed/32265299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.012213
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