Mechanistic Models as Framework for Understanding Biomarker Disposition: Prediction of Creatinine‐Drug Interactions

Creatinine is widely used as a biomarker of glomerular filtration, and, hence, renal function. However, transporter‐mediated secretion also contributes to its renal clearance, albeit to a lesser degree. Inhibition of these transporters causes transient serum creatinine elevation, which can be mistak...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:CPT Pharmacometrics Syst Pharmacol
Prif Awduron: Scotcher, Daniel, Arya, Vikram, Yang, Xinning, Zhao, Ping, Zhang, Lei, Huang, Shiew‐Mei, Rostami‐Hodjegan, Amin, Galetin, Aleksandra
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: John Wiley and Sons Inc. 2020
Pynciau:
Research
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7239336/
https://ncbi.nlm.nih.gov/pubmed/32410382
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/psp4.12508
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