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High Throughput Discovery of Functional Protein Modifications by Hotspot Thermal Profiling
Mass spectrometry has revolutionized the ability to study posttranslationally modified proteoforms from biologic samples, yet we still lack methods to systematically predict, or even prioritize, which modification sites may perturb protein function. Here we describe a proteomic method to detect the...
Αποθηκεύτηκε σε:
| Τόπος έκδοσης: | Nat Methods |
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| Κύριοι συγγραφείς: | , , , , , |
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
2019
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7238970/ https://ncbi.nlm.nih.gov/pubmed/31384043 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41592-019-0499-3 |
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