Antitumor activity of Z-endoxifen in aromatase inhibitor-sensitive and aromatase inhibitor-resistant estrogen receptor-positive breast cancer

BACKGROUND: The tamoxifen metabolite, Z-endoxifen, demonstrated promising antitumor activity in endocrine-resistant estrogen receptor-positive (ER+) breast cancer. We compared the antitumor activity of Z-endoxifen with tamoxifen and letrozole in the letrozole-sensitive MCF7 aromatase expressing mode...

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Gepubliceerd in:Breast Cancer Res
Hoofdauteurs: Jayaraman, Swaathi, Hou, Xiaonan, Kuffel, Mary J., Suman, Vera J., Hoskin, Tanya L., Reinicke, Kathryn E., Monroe, David G., Kalari, Krishna R., Tang, Xiaojia, Zeldenrust, Megan A., Cheng, Jingfei, Bruinsma, Elizabeth S., Buhrow, Sarah A., McGovern, Renee M., Safgren, Stephanie L., Walden, Chad A., Carter, Jodi M., Reid, Joel M., Ingle, James N., Ames, Matthew M., Hawse, John R., Goetz, Matthew P.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: BioMed Central 2020
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7238733/
https://ncbi.nlm.nih.gov/pubmed/32430040
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13058-020-01286-7
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