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Lidocaine Binding Enhances Inhibition of Nav1.7 Channels by the Sulfonamide PF-05089771
PF-05089771 is an aryl sulfonamide Nav1.7 channel blocker that binds to the inactivated state of Nav1.7 channels with high affinity but binds only weakly to channels in the resting state. Such aryl sulfonamide Nav1.7 channel blockers bind to the extracellular surface of the S1-S4 voltage-sensor segm...
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| Опубликовано в: : | Mol Pharmacol |
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| Главные авторы: | , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
The American Society for Pharmacology and Experimental Therapeutics
2020
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7237866/ https://ncbi.nlm.nih.gov/pubmed/32193331 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.119.118380 |
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