Deletion of M-Opsin Prevents M Cone Degeneration in a Mouse Model of Leber Congenital Amaurosis

Mutations in retinoid isomerase (RPE65) or lecithin-retinol acyltransferase (LRAT) disrupt 11-cis-retinal synthesis and cause Leber congenital amaurosis (LCA). Despite the success of recent RPE65 gene therapy, follow-up studies show that patients continue to experience photoreceptor degeneration and...

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Udgivet i:Am J Pathol
Main Authors: Xu, Hui, Enemchukwu, Nduka, Zhong, Xiaoyue, Zhang, Olivia, Fu, Yingbin
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Investigative Pathology 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7237827/
https://ncbi.nlm.nih.gov/pubmed/32084365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2020.01.005
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