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Cone opsin determines the time course of cone photoreceptor degeneration in Leber congenital amaurosis
Mutations in RPE65 or lecithin-retinol acyltransferase (LRAT) disrupt 11-cis-retinal recycling and cause Leber congenital amaurosis (LCA), the most severe retinal dystrophy in early childhood. We used Lrat(−)(/−), a murine model for LCA, to investigate the mechanism of rapid cone degeneration. Altho...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3102375/ https://ncbi.nlm.nih.gov/pubmed/21555576 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1017127108 |
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