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Cone opsin determines the time course of cone photoreceptor degeneration in Leber congenital amaurosis

Mutations in RPE65 or lecithin-retinol acyltransferase (LRAT) disrupt 11-cis-retinal recycling and cause Leber congenital amaurosis (LCA), the most severe retinal dystrophy in early childhood. We used Lrat(−)(/−), a murine model for LCA, to investigate the mechanism of rapid cone degeneration. Altho...

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Bibliografski detalji
Glavni autori: Zhang, Tao, Zhang, Ning, Baehr, Wolfgang, Fu, Yingbin
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2011
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3102375/
https://ncbi.nlm.nih.gov/pubmed/21555576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1017127108
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