MHC-I genotype and tumor mutational burden predict response to immunotherapy

BACKGROUND: Immune checkpoint blockade (ICB) with antibodies inhibiting cytotoxic T lymphocyte-associated protein-4 (CTLA-4) and programmed cell death protein-1 (PD-1) (or its ligand (PD-L1)) can stimulate immune responses against cancer and have revolutionized the treatment of tumors. The influence...

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Detalhes bibliográficos
Publicado no:Genome Med
Main Authors: Goodman, Aaron M., Castro, Andrea, Pyke, Rachel Marty, Okamura, Ryosuke, Kato, Shumei, Riviere, Paul, Frampton, Garrett, Sokol, Ethan, Zhang, Xinlian, Ball, Edward D., Carter, Hannah, Kurzrock, Razelle
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2020
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Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7236948/
https://ncbi.nlm.nih.gov/pubmed/32430031
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13073-020-00743-4
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