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Tumor Mutational Burden as an Independent Predictor of Response to Immunotherapy in Diverse Cancers

Immunotherapy induces durable responses in a subset of patients with cancer. High TMB may be a response biomarker for PD-1/PD-L1 blockade in tumors such as melanoma and non-small cell lung cancer (NSCLC). Our aim was to examine the relationship between TMB and outcome in diverse cancers treated with...

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發表在:Mol Cancer Ther
Main Authors: Goodman, Aaron M., Kato, Shumei, Bazhenova, Lyudmila, Patel, Sandip P., Frampton, Garrett M., Miller, Vincent, Stephens, Philip J., Daniels, Gregory A., Kurzrock, Razelle
格式: Artigo
語言:Inglês
出版: 2017
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5670009/
https://ncbi.nlm.nih.gov/pubmed/28835386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-17-0386
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