Mechanism and effects of pulsatile GABA secretion from cytosolic pools in the human beta cell

Pancreatic beta cells synthesize and secrete the neurotransmitter γ-aminobutyric acid (GABA) as a paracrine and autocrine signal to help regulate hormone secretion and islet homeostasis. Islet GABA release has classically been described as a secretory vesicle-mediated event. Yet, a limitation of the...

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Detalhes bibliográficos
Publicado no:Nat Metab
Main Authors: Menegaz, Danusa, Hagan, D. Walker, Almaça, Joana, Cianciaruso, Chiara, Rodriguez-Diaz, Rayner, Molina, Judith, Dolan, Robert M., Becker, Matthew W., Schwalie, Petra C., Nano, Rita, Lebreton, Fanny, Kang, Chen, Sah, Rajan, Gaisano, Herbert Y., Berggren, Per-Olof, Baekkeskov, Steinunn, Caicedo, Alejandro, Phelps, Edward A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7236889/
https://ncbi.nlm.nih.gov/pubmed/32432213
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42255-019-0135-7
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