Pharmacophore-Based Design of New Chemical Scaffolds as Translational Readthrough-Inducing Drugs (TRIDs)

[Image: see text] Translational readthrough-inducing drugs (TRIDs) rescue the functional full-length protein expression in genetic diseases, such as cystic fibrosis, caused by premature termination codons (PTCs). Small molecules have been developed as TRIDs to trick the ribosomal machinery during re...

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Bibliografiske detaljer
Udgivet i:ACS Med Chem Lett
Main Authors: Tutone, Marco, Pibiri, Ivana, Perriera, Riccardo, Campofelice, Ambra, Culletta, Giulia, Melfi, Raffaella, Pace, Andrea, Almerico, Anna Maria, Lentini, Laura
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2020
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7236267/
https://ncbi.nlm.nih.gov/pubmed/32435380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.9b00609
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