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Deciphering the Nonsense Readthrough Mechanism of Action of Ataluren: An in Silico Compared Study

[Image: see text] Ataluren was reported to suppress nonsense mutations by promoting the readthrough of premature stop codons, although its mechanism of action (MOA) is still debated. The likely interaction of Ataluren with CFTR-mRNA has been previously studied by molecular dynamics. In this work we...

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書誌詳細
出版年:ACS Med Chem Lett
主要な著者: Tutone, Marco, Pibiri, Ivana, Lentini, Laura, Pace, Andrea, Almerico, Anna Maria
フォーマット: Artigo
言語:Inglês
出版事項: American Chemical Society 2019
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6466511/
https://ncbi.nlm.nih.gov/pubmed/30996790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.8b00558
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