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Deciphering the Nonsense Readthrough Mechanism of Action of Ataluren: An in Silico Compared Study
[Image: see text] Ataluren was reported to suppress nonsense mutations by promoting the readthrough of premature stop codons, although its mechanism of action (MOA) is still debated. The likely interaction of Ataluren with CFTR-mRNA has been previously studied by molecular dynamics. In this work we...
Αποθηκεύτηκε σε:
| Τόπος έκδοσης: | ACS Med Chem Lett |
|---|---|
| Κύριοι συγγραφείς: | , , , , |
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
American Chemical
Society
2019
|
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6466511/ https://ncbi.nlm.nih.gov/pubmed/30996790 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.8b00558 |
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