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Deciphering the Nonsense Readthrough Mechanism of Action of Ataluren: An in Silico Compared Study
[Image: see text] Ataluren was reported to suppress nonsense mutations by promoting the readthrough of premature stop codons, although its mechanism of action (MOA) is still debated. The likely interaction of Ataluren with CFTR-mRNA has been previously studied by molecular dynamics. In this work we...
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| 出版年: | ACS Med Chem Lett |
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| 主要な著者: | , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Chemical
Society
2019
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| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6466511/ https://ncbi.nlm.nih.gov/pubmed/30996790 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.8b00558 |
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