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Deciphering the Nonsense Readthrough Mechanism of Action of Ataluren: An in Silico Compared Study

[Image: see text] Ataluren was reported to suppress nonsense mutations by promoting the readthrough of premature stop codons, although its mechanism of action (MOA) is still debated. The likely interaction of Ataluren with CFTR-mRNA has been previously studied by molecular dynamics. In this work we...

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Publicat a:ACS Med Chem Lett
Autors principals: Tutone, Marco, Pibiri, Ivana, Lentini, Laura, Pace, Andrea, Almerico, Anna Maria
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2019
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6466511/
https://ncbi.nlm.nih.gov/pubmed/30996790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.8b00558
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