Sigma Receptor Ligands Carrying a Nitric Oxide Donor Nitrate Moiety: Synthesis, In Silico, and Biological Evaluation

[Image: see text] We report the development of molecular hybrids in which a nitrate group serving as nitric oxide (NO) donor is covalently joined to σ receptor ligands to give candidates for double-targeted cancer therapy. The compounds have been evaluated in radioligand binding assay at both σ rece...

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發表在:ACS Med Chem Lett
Main Authors: Amata, Emanuele, Dichiara, Maria, Gentile, Davide, Marrazzo, Agostino, Turnaturi, Rita, Arena, Emanuela, La Mantia, Alfonsina, Tomasello, Barbara Rita, Acquaviva, Rosaria, Di Giacomo, Claudia, Rescifina, Antonio, Prezzavento, Orazio
格式: Artigo
語言:Inglês
出版: American Chemical Society 2020
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7236233/
https://ncbi.nlm.nih.gov/pubmed/32435401
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.9b00661
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