Chiral Separation, X-ray Structure, and Biological Evaluation of a Potent and Reversible Dual Binding Site AChE Inhibitor

[Image: see text] Acetylcholinesterase (AChE) inhibitors (AChEIs) still remain the leading therapeutic options for the symptomatic treatment of cognitive deficits associated with mild-to-moderate Alzheimer’s disease. The search for new AChEIs benefits from well-established knowledge of the molecular...

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Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Main Authors: Catto, Marco, Pisani, Leonardo, de la Mora, Eugenio, Belviso, Benny Danilo, Mangiatordi, Giuseppe Felice, Pinto, Andrea, Palma, Annalisa De, Denora, Nunzio, Caliandro, Rocco, Colletier, Jacques-Philippe, Silman, Israel, Nicolotti, Orazio, Altomare, Cosimo Damiano
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2020
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7236231/
https://ncbi.nlm.nih.gov/pubmed/32435398
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.9b00656
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