Structural and in Vivo Characterization of Tubastatin A, a Widely Used Histone Deacetylase 6 Inhibitor

[Image: see text] Tubastatin A, a tetrahydro-γ-carboline-capped selective HDAC6 inhibitor (HDAC6i), was rationally designed 10 years ago, and has become the best investigated HDAC6i to date. It shows efficacy in various neurological disease animal models, as HDAC6 plays a crucial regulatory role in...

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Bibliografiset tiedot
Julkaisussa:ACS Med Chem Lett
Päätekijät: Shen, Sida, Svoboda, Michal, Zhang, Guangming, Cavasin, Maria A., Motlova, Lucia, McKinsey, Timothy A., Eubanks, James H., Bařinka, Cyril, Kozikowski, Alan P.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Chemical Society 2020
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7236036/
https://ncbi.nlm.nih.gov/pubmed/32435374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.9b00560
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