Effect of the Most Relevant CYP3A4 and CYP3A5 Polymorphisms on the Pharmacokinetic Parameters of 10 CYP3A Substrates

Several cytochrome P450 (CYP) CYP3A polymorphisms were associated with reduced enzyme function. We aimed to evaluate the influence of these alleles on the pharmacokinetic parameters (PK) of several CYP3A substrates. We included 251 healthy volunteers who received a single dose of ambrisentan, atorva...

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Detalhes bibliográficos
Publicado no:Biomedicines
Main Authors: Saiz-Rodríguez, Miriam, Almenara, Susana, Navares-Gómez, Marcos, Ochoa, Dolores, Román, Manuel, Zubiaur, Pablo, Koller, Dora, Santos, María, Mejía, Gina, Borobia, Alberto M., Rodríguez-Antona, Cristina, Abad-Santos, Francisco
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7235792/
https://ncbi.nlm.nih.gov/pubmed/32331352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biomedicines8040094
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