Effect of the Most Relevant CYP3A4 and CYP3A5 Polymorphisms on the Pharmacokinetic Parameters of 10 CYP3A Substrates

Several cytochrome P450 (CYP) CYP3A polymorphisms were associated with reduced enzyme function. We aimed to evaluate the influence of these alleles on the pharmacokinetic parameters (PK) of several CYP3A substrates. We included 251 healthy volunteers who received a single dose of ambrisentan, atorva...

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Bibliografske podrobnosti
izdano v:Biomedicines
Main Authors: Saiz-Rodríguez, Miriam, Almenara, Susana, Navares-Gómez, Marcos, Ochoa, Dolores, Román, Manuel, Zubiaur, Pablo, Koller, Dora, Santos, María, Mejía, Gina, Borobia, Alberto M., Rodríguez-Antona, Cristina, Abad-Santos, Francisco
Format: Artigo
Jezik:Inglês
Izdano: MDPI 2020
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7235792/
https://ncbi.nlm.nih.gov/pubmed/32331352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biomedicines8040094
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