Genetic and epigenetic intratumor heterogeneity impacts prognosis of lung adenocarcinoma

Intratumor heterogeneity (ITH) of genomic alterations may impact prognosis of lung adenocarcinoma (LUAD). Here, we investigate ITH of somatic copy number alterations (SCNAs), DNA methylation, and point mutations in lung cancer driver genes in 292 tumor samples from 84 patients with LUAD. LUAD sample...

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Publicado en:Nat Commun
Autores principales: Hua, Xing, Zhao, Wei, Pesatori, Angela C., Consonni, Dario, Caporaso, Neil E., Zhang, Tongwu, Zhu, Bin, Wang, Mingyi, Jones, Kristine, Hicks, Belynda, Song, Lei, Sampson, Joshua, Wedge, David C., Shi, Jianxin, Landi, Maria Teresa
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group UK 2020
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7235245/
https://ncbi.nlm.nih.gov/pubmed/32424208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-16295-5
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