UGCG overexpression leads to increased glycolysis and increased oxidative phosphorylation of breast cancer cells

The only enzyme in the glycosphingolipid (GSL) metabolic pathway, which produces glucosylceramide (GlcCer) de novo is UDP-glucose ceramide glucosyltransferase (UGCG). UGCG is linked to pro-cancerous processes such as multidrug resistance development and increased proliferation in several cancer type...

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Publicat a:Sci Rep
Autors principals: Schömel, Nina, Gruber, Lisa, Alexopoulos, Stephanie J., Trautmann, Sandra, Olzomer, Ellen M., Byrne, Frances L., Hoehn, Kyle L., Gurke, Robert, Thomas, Dominique, Ferreirós, Nerea, Geisslinger, Gerd, Wegner, Marthe-Susanna
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7234995/
https://ncbi.nlm.nih.gov/pubmed/32424263
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-65182-y
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