Discovery and development of small-molecule inhibitors of glycogen synthase

The over-accumulation of glycogen appears as a hallmark in various glycogen storage diseases (GSDs), including Pompe, Cori, Andersen and Lafora disease. Accumulating evidence suggests that suppression of glycogen accumulation represents a potential therapeutic approach for treating these GSDs. Using...

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Pubblicato in:J Med Chem
Autori principali: Tang, Buyun, Frasinyuk, Mykhaylo S., Chikwana, Vimbai M., Mahalingan, Krishna K., Morgan, Cynthia A., Segvich, Dyann M., Bondarenko, Svitlana P., Mrug, Galyna P., Wyrebek, Przemyslaw, Watt, David S., DePaoli-Roach, Anna A., Roach, Peter J., Hurley, Thomas D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7233370/
https://ncbi.nlm.nih.gov/pubmed/32134266
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.9b01851
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