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Spirometric traits show quantile-dependent heritability, which may contribute to their gene-environment interactions with smoking and pollution
BACKGROUND: “Quantile-dependent expressivity” refers to a genetic effect that is dependent upon whether the phenotype (e.g., spirometric data) is high or low relative to its population distribution. Forced vital capacity (FVC), forced expiratory volume in 1 second (FEV(1)), and the FEV(1)/FVC ratio...
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| Publicado en: | PeerJ |
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| Autor Principal: | |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
PeerJ Inc.
2020
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7233273/ https://ncbi.nlm.nih.gov/pubmed/32461834 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7717/peerj.9145 |
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