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Quantile-dependent expressivity of plasma adiponectin concentrations may explain its sex-specific heritability, gene-environment interactions, and genotype-specific response to postprandial lipemia

BACKGROUND: “Quantile-dependent expressivity” occurs when the effect size of a genetic variant depends upon whether the phenotype (e.g. adiponectin) is high or low relative to its distribution. We have previously shown that the heritability (h(2)) of adiposity, lipoproteins, postprandial lipemia, pu...

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Vydáno v:PeerJ
Hlavní autor: Williams, Paul T.
Médium: Artigo
Jazyk:Inglês
Vydáno: PeerJ Inc. 2020
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7568478/
https://ncbi.nlm.nih.gov/pubmed/33088620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7717/peerj.10099
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