Cancer Cells Upregulate NRF2 Signaling to Adapt to Autophagy Inhibition

While autophagy is thought to be an essential process in some cancer cells, it is unknown if or how such cancer cells can circumvent autophagy inhibition. To address this, we developed a CRISPR/ Cas9 assay with dynamic live-cell imaging to measure acute effects of knockout (KO) of autophagy genes co...

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Udgivet i:Dev Cell
Main Authors: Towers, Christina G., Fitzwalter, Brent E., Regan, Daniel, Goodspeed, Andrew, Morgan, Michael J., Liu, Chang-Wei, Gustafson, Daniel L., Thorburn, Andrew
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7233142/
https://ncbi.nlm.nih.gov/pubmed/31378590
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2019.07.010
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