Autophagy inhibition improves anti-cancer drugs via FOXO3a activation

Por Fitzwalter, Brent E., Thorburn, Andrew
Publicado no Oncotarget (2018)

FOXO3 links autophagy to apoptosis

Por Fitzwalter, Brent E., Thorburn, Andrew
Publicado no Autophagy (2018)

LGG-37. ASSESSMENT OF EARLY STAGE AUTOPHAGY INHIBITION IN BRAF(V600E) BRAIN TUMOR CELL RESPONSE TO CHEMOTHERAPY

Por Zahedi, Shadi, Fitzwalter, Brent E, Gustafson, Daniel L, Morin, Andrew, Desmarais, Michele, Hoffman, Lindsey M, Levy, Jean M Mulcahy
Publicado no Neuro Oncol (2018)

Cancer Cells Upregulate NRF2 Signaling to Adapt to Autophagy Inhibition

Por Towers, Christina G., Fitzwalter, Brent E., Regan, Daniel, Goodspeed, Andrew, Morgan, Michael J., Liu, Chang-Wei, Gustafson, Daniel L., Thorburn, Andrew
Publicado no Dev Cell (2019)

Metastatic cells are preferentially vulnerable to lysosomal inhibition

Por Morgan, Michael J., Fitzwalter, Brent E., Owens, Charles R., Powers, Rani K., Sottnik, Joseph L., Gamez, Graciela, Costello, James C., Theodorescu, Dan, Thorburn, Andrew
Publicado no Proc Natl Acad Sci U S A (2018)

Effect of early-stage autophagy inhibition in BRAF(V600E) autophagy-dependent brain tumor cells

Por Zahedi, Shadi, Fitzwalter, Brent E., Morin, Andrew, Grob, Sydney, Desmarais, Michele, Nellan, Anandani, Green, Adam L., Vibhakar, Rajeev, Hankinson, Todd C., Foreman, Nicholas K., Mulcahy Levy, Jean M.
Publicado no Cell Death Dis (2019)

Autophagy inhibition mediates apoptosis sensitization in cancer therapy by relieving FOXO3a turnover

Por Fitzwalter, Brent E., Towers, Christina G., Sullivan, Kelly D., Andrysik, Zdenek, Hoh, Maria, Ludwig, Michael, O’Prey, Jim, Ryan, Kevin M., Espinosa, Joaquin M., Morgan, Michael J., Thorburn, Andrew
Publicado no Dev Cell (2018)

ZZ-dependent regulation of p62/SQSTM1 in autophagy

Por Zhang, Yi, Mun, Su Ran, Linares, Juan F., Ahn, JaeWoo, Towers, Christina G., Ji, Chang Hoon, Fitzwalter, Brent E., Holden, Michael R., Mi, Wenyi, Shi, Xiaobing, Moscat, Jorge, Thorburn, Andrew, Diaz-Meco, Maria T., Kwon, Yong Tae, Kutateladze, Tatiana G.
Publicado no Nat Commun (2018)

Autophagy inhibition overcomes multiple mechanisms of resistance to BRAF inhibition in brain tumors

Por Mulcahy Levy, Jean M, Zahedi, Shadi, Griesinger, Andrea M, Morin, Andrew, Davies, Kurtis D, Aisner, Dara L, Kleinschmidt-DeMasters, BK, Fitzwalter, Brent E, Goodall, Megan L, Thorburn, Jacqueline, Amani, Vladimir, Donson, Andrew M, Birks, Diane K, Mirsky, David M, Hankinson, Todd C, Handler, Michael H, Green, Adam L, Vibhakar, Rajeev, Foreman, Nicholas K, Thorburn, Andrew
Publicado no eLife (2017)