LGG-37. ASSESSMENT OF EARLY STAGE AUTOPHAGY INHIBITION IN BRAF(V600E) BRAIN TUMOR CELL RESPONSE TO CHEMOTHERAPY

We have previously shown CNS tumors with the BRAF(V600E) mutation are autophagy dependent and late stage autophagy inhibition improves responses to targeted BRAF inhibitors (BRAFi) in sensitive and BRAFi resistant cells. Autophagy is a multi-stage process. Progress within the field has led to the de...

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Veröffentlicht in:Neuro Oncol
Hauptverfasser: Zahedi, Shadi, Fitzwalter, Brent E, Gustafson, Daniel L, Morin, Andrew, Desmarais, Michele, Hoffman, Lindsey M, Levy, Jean M Mulcahy
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2018
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6012672/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy059.378
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